Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade

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Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade.

Short-term muscle denervation is a reproducible model of tissue-specific insulin resistance. To investigate the molecular basis of insulin resistance in denervated muscle, the downstream signaling molecules of the insulin-signaling pathway were examined in intact and denervated soleus muscle of rats. Short-term denervation induced a significant fall in glucose clearance rates (62% of control, P...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism

سال: 2003

ISSN: 0193-1849,1522-1555

DOI: 10.1152/ajpendo.00345.2002